Research Tech

Department Information

Dr. Lockett is an Assistant Professor in the Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine. Her research interests are to investigate the etiology of the vascular abnormalities that mediate vascular remodeling in pulmonary arterial hypertension (PAH), and to identify molecules or pathways to target for therapeutic intervention. Her lab is specifically interested in identifying the role of maladaptive mitochondrial function which may alter metabolic pathways to promote the pathogenesis of PAH. We made the novel discovery that the evolutionarily conserved stress response, the mitochondrial unfolded protein response (UPRmt), promotes vascular remodeling in preclinical models of PAH and promotes a hyper-proliferative phenotype in pulmonary artery smooth muscle and endothelial cells.

Job Summary

This position involves working with tissues from animals as well as preforming cell culture. Common methodology in the lab include molecular biology techniques involving protein and RNA isolation, Western blotting, qPCR, and gene silencing or ectopic expression.

General Responsibilities

• Performs a wide variety of complex experiments and reports results.
• Keeps organized analytical data of performed experiments.
• Provides support for equipment maintenance as needed.
• Acts as a liaison to students and laboratory personnel for training.
• Maintains laboratory supply requisition and management.
• May train junior-level staff.
• May help plan experiments or short-term goals.

Qualifications

Combinations of related education and experience may be considered. Education beyond the minimum required may be substituted for work experience. Work experience beyond the minimum required may be substituted for education.

EDUCATION

Required

• Bachelor's degree in science or related field.

WORK EXPERIENCE

Preferred

• Experience with cell culture and aseptic technique.

SKILLS

Required

• Proficient written and verbal communication skills.
• Maintains a high degree of professionalism.
• Demonstrates time management and priority setting skills.
• Demonstrates a high commitment to quality.
• Possesses flexibility to work in a fast paced, dynamic environment.
• Highly thorough and dependable.

Working Conditions / Demands

The role regularly requires the ability to effectively communicate. The role frequently requires the ability to move about the work environment and to position oneself to operate laboratory equipment effectively. The role requires the ability to move objects weighing up to 25 pounds and will occasionally work near moving mechanical parts. The person in this role must be able to perform the essential functions with or without an accommodation.

Work Location

IU Indianapolis campus