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The Howard Hughes Medical Institute (HHMI) advances the discovery
and sharing of scientific knowledge to benefit us all. As a
biomedical research organization and philanthropy, HHMI supports a
vibrant community of academic researchers, educators, students, and
professionals. Together, we’re unlocking the fundamentals of
biology and building an open, inclusive future for science.
We have an outstanding opportunity for a
Research Technician
II to join
Dr. Xin Jin’s lab at Scripps Research in La
Jolla, California. The Jin lab is investigating how physiology and
genetics impact brain function to understand how these distinct
influences converge in the developing brain. To tackle these
questions, they combine in vivo CRISPR screening with single-cell
multi-omics, spatial genomics, and chemical biology tools. Their
work is deeply collaborative, both within the lab and across
disciplines, and bridges cutting-edge neurotechnology with
fundamental questions in brain development. This integration of
tool-building and mechanistic insight positions them to uncover how
diverse inputs shape the brain’s trajectory in health and disease.
More information about the lab and their work can be found by
visiting
https://www.jin.scripps.edu/
About the Research Technician II role:
As the Research Technician II, you will support studies using
genomic tools to investigate tissue development and homeostasis.
This position will involve mouse handling, molecular biology,
genomics, cell culture, and single-cell sequencing-related
workflows. The successful candidate will work both independently
and collaboratively to perform experiments, maintain accurate
records, troubleshoot protocols, and help generate high-quality
data for ongoing research projects. This is an ideal opportunity
for someone who is passionate about the lab’s work and looking for
a stable, longer-term (ideally 3+ years) career experience.
What we provide:
- An energetic, dynamic, and fun lab team that values innovation,
inclusion, scientific rigor, and collaboration.
Generous and stable research funding from HHMI.
Joining the vibrant Scripps research community.
Career growth, skill building, and professional
development.
Opportunities to be mentored by Dr. Jin and/or senior members
of the team.
Opportunities for authorship/co-authorship on research
publications.
A competitive compensation package with comprehensive health and wellness benefits .
What you’ll do:
- Perform mouse-related laboratory work, including handling,
husbandry coordination, colony tracking, genotyping, tissue
dissection/collection, and molecular analysis, in support of
studies on brain development and neurodevelopmental disease
mechanisms.
- Assist with CRISPR-based perturbation experiments, including
reagent preparation, viral/vector-related workflows, sample
collection, and genomic analysis.
- Carry out core molecular biology techniques, including DNA/RNA
extraction, PCR, qPCR, gel electrophoresis, cloning, and
preparation of sequencing-related materials.
- Support single-cell genomics workflows, including nuclei/cell
preparation, quality control, library preparation support, and
sample submission for sequencing.
- Maintain mammalian cell cultures using sterile technique,
including passaging, transfection/transduction support, and
monitoring of cell health.
- Prepare, organize, and validate experimental reagents, such as
plasmids, oligos, guide RNA libraries, buffers, and cell culture
media.
- Record experimental procedures, sample information, and results
accurately in laboratory notebooks and shared databases.
- Analyze and summarize experimental results, including
genotyping outcomes, QC metrics, and molecular assay data, and
troubleshoot routine issues related to sample quality, molecular
assays, sequencing preparation, or cell culture conditions.
- Maintain laboratory equipment, supplies, and reagent
inventories, and coordinate with lab members on experimental
timelines, animal use, sequencing submissions, and sample tracking
to ensure efficient day-to-day lab operations.
- Adhere to institutional biosafety, animal research, and
laboratory compliance policies, including required documentation
and training.
What you bring:
- A bachelor’s degree in the life sciences is required.
Candidates with master’s degrees are also welcome to apply and will
be considered.
- A minimum of 2-4 years of relevant research experience in an
academic laboratory environment is required.
- Prior experience with mouse handling, mouse colony management,
tissue collection, genotyping, or related animal research
procedures.
- Experience with standard molecular biology techniques such as
DNA/RNA extraction, PCR, qPCR, gel electrophoresis, cloning, or
preparation of sequencing-related samples.
- Experience with mammalian cell culture, sterile technique, cell
passaging, transfection, viral transduction, or cell-based
assays.
- Familiarity with genomics or single-cell sequencing workflows
would be a plus.
- Ability to follow detailed experimental protocols, maintain
organized records, and accurately track samples and reagents.
- Ability to work under minimal supervision, troubleshoot routine
experimental issues, and adapt standard procedures when
needed.
- Willingness to work with mouse models and comply with
institutional animal research, biosafety, and laboratory safety
requirements.
- Strong verbal and written communications skills, interpersonal
skills, and collaboration skills.
- Ability to contribute to fostering and maintaining a positive,
thriving lab culture.
Physical Requirements
Remaining in a normal seated or standing position for extended
periods of time; reaching and grasping by extending hand(s) or
arm(s); dexterity to manipulate objects with fingers, for example
using a keyboard; communication skills using the spoken word;
ability to see and hear within normal parameters; ability to move
about workspace. The position requires mobility, including the
ability to move materials weighing up to several pounds (such as a
laptop computer or tablet). Work may involve possible exposure to
malodorous vapors, low dose radiation, contamination by toxic
chemicals and acids and presence of carcinogenic substances or
other hazardous materials.
Persons with disabilities may be able to perform the essential
duties of this position with reasonable accommodation. Requests for
reasonable accommodation will be evaluated on an individual
basis.
Please Note:
This job description sets forth the job’s principal duties,
responsibilities, and requirements; it should not be construed as
an exhaustive statement, however. Unless they begin with the word
“may,” the Essential Duties and Responsibilities described above
are “essential functions” of the job, as defined by the Americans
with Disabilities Act.
Compensation and Benefits
Our employees are compensated from a total rewards perspective in
many ways for their contributions to our mission, including
competitive pay, exceptional health benefits, retirement plans,
time off, and a range of recognition and wellness programs. Visit
our
Benefits at HHMI site to learn more.
Hiring Pay Range
$22.88 - $28.61
Pay Type:
Hourly
The posted range reflects HHMI’s good faith estimate of the
anticipated hiring salary range for this role at the time of
posting. Actual hiring compensation is determined by a candidate’s
qualifications, experience, and internal equity.
HHMI is an Equal Opportunity
Employer
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eligibility of all new hires.