Research Technician-Oser Lab

OVERVIEW

The Oser Laboratory studies the biology of small cell lung cancer (SCLC) with the goal of identifying new therapeutic targets and strategies to improve treatment for patients. The lab’s research focuses on molecular mechanisms that control neuroendocrine differentiation, the cell cycle, lineage plasticity, and tumor immunogenicity in SCLC. A central focus of the lab is understanding how epigenetic regulatory factors control lineage-defining transcription factors that drive SCLC biology using functional genomics approaches. We also use CRISPR/Cas9-based genome editing in genetically engineered mouse models to study the roles of candidate oncogenes and tumor suppressor genes during SCLC tumorigenesis and to understand how genetic and epigenetic changes influence SCLC subtype identity and tumor immunogenicity.

The Oser Lab is seeking a highly motivated research technician to join a research team focused on the research above. This individual will assist with ongoing experiments of Dr. Oser’s Lab and other members of the Oser Lab and help manage the lab's daily operations. Good organizational and communications skills are essential for this role as well as the ability to work with a team. The position also will require a core foundation of molecular and cellular biology with some experience in tissue culture, and willingness to work with mice.

https://oserlab.dana-farber.org/

• Set up, adjust, calibrate, clean, maintain and troubleshoot equipment
• Clean, maintain and prepare supplies and work areas and may be responsible for ordering of supplies. Collaborates with Purchasing and may be responsible for negotiating with vendors
• Conduct standardized biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances, such as blood, drugs, and animals
• Isolate, identify and prepare specimens for examination
• Analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to staff
• Participate in grant application process and manuscript preparation as required
• Maintains detailed notebook of all work-related activities
• Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory
• Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications
• May be responsible for the development, modification and improvement of standard operating procedures
• Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties
• May be responsible for designing and executing advanced experiments and setting strategy
• May be responsible for the examination of animals and specimens to detect the presence of disease or other problems
• May be responsible for monitoring laboratory budgets

KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:

• Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred
• Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff
• Ability to analyze information and use logic to address work-related issues and problems
• Must have attention to detail and be thorough in completing work tasks
• Ability to work within a team environment

MINIMUM JOB QUALIFICATIONS:

The position requires a bachelor’s degree, preferably in biology or chemistry, with no prior professional experience necessary. Candidates will learn and apply technical principles, processes, and concepts, use institutional policies to address routine issues, and work on problems of limited scope. The role involves following standard practices to analyze situations or data and building stable internal working relationships.

SUPERVISORY RESPONSIBILITIES:

No supervisory responsibilities. Normally receives detailed instructions on all work.

PATIENT CONTACT:

None