Role of the extracellular matrix in skeletal muscle stem cell function

About the Project

The regenerative capacity of skeletal muscle stem cells, also called satellite cells, is essential for muscle homeostasis and to maintain healthy muscles throughout the lifespan. The micro-environment of satellite cells plays a critical role in ensuring that the stem cells remain quiescent when not needed and in controlling the balance between differentiation and self-renewal when satellite cells are activated. The extracellular matrix is an important player in this micro-environment. We have previously demonstrated that one component of the extracellular matrix, Laminin-111, is remodelled in a dynamic manner during the activation and differentiation of skeletal muscle stem cells. This project aims at deciphering further how different extracellular matrix components contribute to regulating different effects in skeletal muscle stem cells using mouse genetic models as well as human iPSC-derived skeletal muscle organoids.

Candidates applying to this project should have a minimum 2.1 undergraduate honours degree (or equivalent) and/or MSc degree with Merit in a relevant science subject. It will be an advantage if candidates have a previous research experience in stem cell biology.

For more details on the entry requirements and research at the University of Sheffield, and how to apply visit our school’s webpages at https://www.sheffield.ac.uk/biosciences/postgraduate/phd

Funding Notes

Note that this project is for self-funded students only. Applicants should enquire about registration fees before applying.

First class or upper second 2(i) in a relevant subject. To formally apply for a PhD, you must complete the University's application form using the following link:

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