Senior Data Scientist/Computational Biologist

Job Description

The Core for Computational Biomedicine (CCB) in the Department of Biomedical Informatics (DBMI) at Harvard Medical School (HMS) is looking for an experienced Senior Data Scientist/Computational Biologist to advance in CCB's mission to leverage data and computation to transform research and improve health. CCB provides computational and analytic resources to advance scientific discovery within HMS through its multi-disciplinary team of computational and quantitative scientists who work on collaborative projects both within the center and with members of the HMS community. The role will involve processing, analyzing, and integrating public and newly generated single-cell and spatial multi-omics datasets in collaboration with experimental labs at HMS. This will include developing sustainable tools, software packages, and integrated data science products that empower research labs to explore, analyze, and interpret their data.

Responsibilities include:

Faculty-facing analytics and computational biology support

• Lead integrative data analyses for HMS research groups, with emphasis on single-cell and multi-omic datasets. Execute projects with clearly defined scope independently and in partnership with HMS faculty collaborators, provide technical guidance, and communicate results in a clear, actionable manner.

Development and maintenance of scalable, reproducible pipelines

• Design, implement, document, and maintain robust analysis workflows (e.g., QC, integration, statistical modeling, reporting) to support repeatable, high-quality computational research across multiple projects.

AI-enabled methods and applied research tooling

• Evaluate and implement AI-assisted approaches that accelerate research workflows (e.g., knowledge extraction, annotation support, literature review and writing workflows) while ensuring scientific rigor, reproducibility, and responsible use.

Training, workshops, and internal enablement

• Develop and deliver hands-on workshops and learning materials for HMS researchers; provide office hours and consultation to promote best practices in computational biology, reproducible research, and AI-enabled workflows.

Open-source software and biomedical data asset development

• Contribute to and maintain open-source software and data resources (including distribution through established ecosystems such as Bioconductor and PyPI), support releases and user documentation, and engage with external developer communities to increase adoption and impact.