"Senior Research Investigator"

Job Description Summary

In this position, the candidate will design, manufacture and test new constructs for in vivo T cell and hematopoietic stem cell transduction. Experiments will range from in vitro demonstration of antigen-specific transduction of candidate cell subsets under various culture conditions, to testing their anti-tumor function, through to in vivo injection and determination of pharmacokinetics/biodistribution along with on-target specificity and anti-tumor effect. In addition, the candidate will oversee and teach new graduate student and post-doctoral scholar experimental skills including molecular cloning, viral production and titration, cell culture, T cell function studies, T cell engineering, flow cytometry and sequencing analysis, in vivo experimental design and analysis.

Job Responsibilities

• Molecular biology: cloning
• Viral (e.g. lentiviral) production, titration, characterization and validation
• In vitro T cell and HSC transduction: optimization of conditions, demonstration of on-target specificity
• In vivo experiments: injection of mice, in vivo imaging, bleeding/organ extraction and analysis using flow, microscopy and transcriptomic techniques (assisted by other lab members as needed)
• On-boarding, teaching, mentoring and supervision of junior lab members e.g. graduate students
• Perform data analysis and other aspects of quantitative and qualitative research as well as theoretical research
• Review, edit, format, and write manuscripts for publication and of grant proposals
• Assist with and often direct the design and implementation of original surveys
• Perform data collection and management
• Administer literature reviews
• Other research and administrative duties
• Oversee laboratory operations.
• Assist PI, graduate students, and postdoctoral fellows with experimental procedures and analysis.
• Grant development
• Data analysis
• Conduct biochemical and molecular biology assays, including chemical extractions, PCR, RT-PCR, sub-cloning, and Western blotting, animal, Protocol Development.
• Other duties and responsibilities as assigned

Qualifications

Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.

This position is contingent upon grant funding.

Job Location

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$79,500.00 - $95,000.00 Annual Rate

To apply

visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/Smilow-Center-for-Translational/Senior--Research-Investigator_JR00115834-1