"Senior Research Technician"

The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology Lab that combines a broad range of laboratory techniques to study the pathways and protein complexes involved in the regulation of protein homeostasis often associated with human diseases, including cancer. Using our knowledge of the cellular degradation machinery, we use structure and computational guided approaches to develop and test new molecules that hijack the ubiquitin proteasome system for targeted protein degradation. Combining fundamental mechanistic insights with translational chemical biology research, we are pioneering new therapeutic avenues.

The Fischer lab (https://fischerlab.dana-farber.org/) seeks a highly motivated individual to join the team as a SENIOR RESEARCH TECHNICIAN. This individual will be an important member of our research team and will be centrally involved in assisting various research projects of the Fischer Lab. In addition to the bench-based research, responsibilities will also include some aspects of laboratory management and organization. Training is available in all aspects of experimental research.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Responsible for the operation and maintenance of Biacore 8K SPR instrument, including compound screening and troubleshooting
• Prepares lab reagents and media
• Performs protein expression and purification procedures
• Conduct standardized biological or biochemical assays and laboratory analyses, eg. TR-FRET, FP, pull downs, cell-based assays, western blot, flow cytometry
• Analyzes experimental data and interpret results to write reports, presentations, grant and publication preparation
• Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
• Maintains detailed notebook of all work-related activities
• Operation and maintenance of standard lab equipment
• Maintains and orders laboratory supplies
• Communicates with purchasing and may be responsible for negotiating with vendors

KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:

• Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred
• Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff
• Ability to analyze information and use logic to address work-related issues and problems
• Must have attention to detail and be thorough in completing work tasks
• Ability to work within a team environment

MINIMUM JOB QUALIFICATIONS:

• Bachelor's Degree required with a major in biology, chemistry or "pre-med" preferred.
• Research experience (1-4 yr) in molecular biology or biochemistry required
• Prior experience with SPR preferred
• Ability to analyze information and use logic to address work-related issues and problems.
• Must have close attention to detail and consistent work habits.
• Ability to work within a team environment.
• A minimum time commitment of 2 years is preferred.

SUPERVISORY RESPONSIBILITIES:

No supervisory responsibilities. Normally receives general instructions on routine work, detailed instructions on new projects or assignments.

PATIENT CONTACT:

None