Senior Technician
Position Summary
We are seeking a full-time Senior Technician to join Dr. Neil Shneider?s lab in the Motor Neuron Center at Columbia University Irving Medical Center. The Senior Technician will join an ongoing research effort using novel mouse models of ALS/FTD and human tissue samples to explore molecular and cellular mechanisms underlying neurodegeneration in ALS, frontotemporal dementia (FTD) and related disorders.
Responsibilities
The Senior Technician will:
- Carry out basic histological preparations of human and mouse tissues using existing protocols or developing and optimizing additional immunohistochemical methods as necessary
- Analyze stained tissues using advanced imaging techniques, including confocal microscopy
- Perform molecular biology and biochemical experiments, such as western blotting, electrophoresis, RNA/DNA/Protein isolations, and PCR
- Develop and maintain IACUC protocols while also managing the laboratory?s mouse colony through husbandry, genotyping and a range of molecular, cellular and behavioral assays to be characterize different mouse lines
- Maintain laboratory equipment and records, perform quality control and quality assurance activities as needed.
- Perform miscellaneous functions required to maintain operation of the laboratory such as liaising with the university EH&S office, ensuring the lab is compliant with state, local and university rules and regulations and ordering reagents for lab work.
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