"Sr. Research Investigator"

Job Description Summary

The Armellino Center of Excellence for Williams Syndrome at Penn and CHOP is seeking a Senior Research Investigator, who will initiate, contribute and manage development of multiple research projects and study protocols of Dr. Mark Levin. Dr. Levin's studies are focused on cardiovascular manifestation of Williams syndrome, with specific emphasis on sudden cardiac death. Selected candidate will be leading the animal studies, conducting electrophysiology experiments, including those requiring experience with patch clamp technique. To ensure success of all researches/clinical studies, Senior Research Investigator will work with Principal Investigator, Dr. Mark Levin, and will closely interact with post doctoral fellows and students in the laboratory, as well as will participate in developing and following safety procedures and research SOPs and protocols for general laboratory practices, in compliance with safety regulations. It is anticipated that Senior Research Investigator will assist with preparation of conference presentations and with preparation of drafts of manuscripts to submitted to peer-reviewed journals.

Job Description

The Senior Research Investigator will initiate, contribute and manage development of multiple research projects and study protocols of Dr. Mark Levin. Dr. Levin's studies are focused on cardiovascular manifestation of Williams syndrome, with specific emphasis on sudden cardiac death. Selected candidate will be leading the animal studies, including whole animal, organ level and isolated cardiomyocyte electrophysiology experiments. These include in vivo cardiac electrophysiology testing, optical mapping with voltage and calcium sensitive dyes and isolated cardiomyocyte studies using whole cell patch clamp, mycoyte contractility and calcium imaging techniques. To ensure success of all researches/clinical studies, Senior Research Investigator will work with Principal Investigator, Dr. Mark Levin, and will closely interact with postdoctoral fellows and students in the laboratory, as well as will participate in developing and following safety procedures and research SOPs and protocols for general laboratory practices, in compliance with safety regulations. It is anticipated that Senior Research Investigator will assist with preparation of conference presentations and with preparation of drafts of manuscripts to submitted to peer-reviewed journals. Desired individual will both plan experiments, troubleshoot commonly occurring problems and should be able to interpret data quality and results.

Duties will include but not limited to:

• Experimental design
• Conducting experiments at the bench
• Conducting animal experiments
• Data analysis
• Preparing manuscripts
• Presenting data at conferences and appropriate professional meetings
• Perform additional duties as assigned

Contingent upon funding

Qualifications

• Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of post doc experience is required.
• Expertise in designing and carrying out cellular and whole animal elcetrophysiology experiments involving optical mapping with voltage sensitive dyes, isolating ventricular myocytes from murine models for use in whole-cell patch clamp studies and calcium transient recordings and in vivo mouse cardiac electrical studies using programmed electrical stimulation. PREFERRED

Job Location

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$79,500.00 - $100,000.00 Annual Rate

Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job's level. Internal organization and peer data at Penn are also considered.

Equal Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

To Apply

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