Staff Scientist - Biochemistry

Position Summary

Center for Drug Discovery is seeking a highly motivated researcher to join our multidisciplinary drug discovery team. This role offers a unique opportunity to bridge the gap between academic innovation and "real-world" therapeutic development.

The successful candidate will be responsible for lead optimization of novel protein aggregate degraders, utilizing both proteasome- and autophagosome-targeting modalities. The candidate will receive hands-on training focusing on the enhancement of potency and optimization of drug-like properties (stability, permeability, PK/PD model, etc.). Additionally, the researcher will develop innovative chemical tools and probes to interrogate fundamental biologic processes and mechanism of action.

Designs research protocols. Assists in developing and conducting research projects, including experiment design, data analysis and documentation of experiment results.

Job Description

Primary Duties & Responsibilities:

• Following instructions and discussions with the principal investigator, designs research protocols, including developing procedures for the collection, verification and management of data.
• Synthesizes heterocyclic binders and degraders.
• Troubleshoots multi-step heterocyclic synthesis independently.
• Assists with grant preparation and reporting.
• Performs complex statistical analysis of data collected and writes interpretative reports. Verifies the correctness of the data submitted and makes recommendations based on these analyses.
• Documents research topics and prepares and submits papers based on research work to publications and committees for publication or presentation to peers.
• Solves practical problems relating to difficulties with equipment or test subjects. Suggests technical or procedural improvements in testing methods.
• Conducts literature searches related to research project.
• Performs other duties as assigned.

Working Conditions:

• Works in a laboratory environment with potential exposure to biological and chemical hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.