Structural Mass Spectrometry Scientist

Are you looking for a role to utilise and develop your mass spectrometry skills within the context of a world-class mass spectrometry facility? Do you want to work with a broad group of scientists from academia and industry? Do you have a passion for transformational biological and biomedical discovery, and delivering cutting edge outputs where the generation and analysis of data play a key role?

We are looking for a structural mass spectrometry (MS) scientist to join our facility team within the Faculty of Biological Sciences and the Astbury Centre for Structural Molecular Biology. Working with state-of-the-art equipment and utilising your expertise in the field, you will work on multiple projects as a structural mass spectrometry expert in hydrogen-deuterium exchange-MS, native MS, chemical crosslinking-MS, and various top-down and bottom-up proteomics approaches. You will provide expert guidance, training and advice in areas covering sample preparation, optimisation, method development, data acquisition, and data interpretation.

You should have, or be close to completing, a PhD in in chemistry, biochemistry, analytical science, structural molecular biology or related discipline, and experience of at least one structural MS method, and have a passion for studying biological mechanisms relevant to human disease. You will work closely, interactively and collaboratively with the facility team as well as the wider MS community and external partners, and so excellent verbal and written communication and interpersonal skills are essential.

The Mass Spectrometry Facility provides an analytical service for the Faculty of Biological Sciences, the Astbury Centre, and other internal and external collaborators, in addition to carrying out a considerable research programme in collaboration with academic staff. The Mass Spectrometry Facility houses several mass spectrometers (including Orbitrap Eclipse, Orbitrap UHMR, Exploris 240, Waters Bioaccord, Waters Synapt G2Si and Waters Cyclic IMS with HDX robotics).

As a structural mass spectrometry scientist you will support the range of mass spectrometry modalities that are available in the facility, including hydrogen-deuterium exchange, native MS, intact protein mass measurement, proteomics and metabolomics. You will provide an efficient analytical service for users of the Facility, performing analyses for users, give advice to others regarding sample preparation, experimental design and data interpretation, actively establish internal and external links with other research groups and industrial partners, develop new techniques for biomolecular analysis, write technical summaries and project reports, maintain the mass spectrometry and chromatography equipment in good working order, and perform other general laboratory duties.

This role will be based on the university campus. We are open to discussing flexible working arrangements.