"Research Associate in Biochemistry/Structural Biology"

Job summary

The post is funded by the Wellcome Trust to investigate Homologous Recombination in the context of chromosome. To carry out research programmes in RAD51 modulators including FIGNL1 and BRCA2 in modulating RAD51 filament formation. The Research Associate will be expected to submit publications to refereed journals.

The successful candidate will join a multi-disciplinary team of international researchers investigating the structures and mechanisms of large key complexes in DNA damage signaling and repair. The successful candidate will mainly be located at the Francis Crick Institute but will also be able at Imperial College London, South Kensington campus. We employ a combination of biochemistry, biophysics, X-ray crystallography and cryo-electron microscopy techniques, utilizing our excellent facilities at Imperial and the Francis Crick Institute. Successful candidates must hold a PhD in biochemistry, biophysics, structural biology or relevant discipline and have a demonstrated track record in conducting high quality original research. This post is funded by the Wellcome Trust and will be initially for 3 years.

Duties and responsibilities

• To take initiatives in the planning of research.
• To direct the work of small research teams.
• To identify and develop suitable techniques, and apparatus, for the collection and analysis of data.
• To conduct data analysis.
• To ensure the validity and reliability of data at all times.
• To maintain accurate and complete records of all findings.
• To write reports for submission to research sponsors.
• To present findings to colleagues and at conferences.
• To submit publications to refereed journals.

Essential requirements

• Hold a PhD in structural biology or a closely related discipline, or equivalent research, industrial or commercial experience.
• Practical experience within a research environment and / or publication in relevant and refereed journals.
• Practical experience in a broad range of techniques including cryo electron microscopy, enzymology, protein-DNA interactions.
• Practical experience within protein expression and purification.
• Knowledge of DNA repair .
• Knowledge of research methods of macromolecular complexes and nucleic acid interactions.
• Knowledge of research methods involving cryo electron microscopy and image processing.

Further information

This post is full time, fixed term until 31 July 2027 and you will be based at the Crick Institute.

Should you require any further details on the role please contact: Professor Xiaodgon Zhang - xiaodong.zhang@imperial.ac.uk