Computational Genetics • Experimental Genetics & Genomics
Build an ambitious genetics and genomics program in one of the field’s most integrated research environments.
The Department of Molecular and Human Genetics at Baylor College of Medicine invites applications from creative, collaborative investigators whose work will define the next generation of genetic discovery and its translation to human health. We welcome applications at the Assistant, Associate, or Full Professor level from established leaders and rising investigators in computational, experimental, or genuinely cross-disciplinary research.
The Opportunity
We seek Ph.D.- and/or M.D.-trained scientists with a record of rigorous, high-impact scholarship and the potential to sustain an externally funded research program. Successful candidates will establish an independent program, contribute to a highly collaborative scientific community, and participate in the education and mentorship of trainees. Research may address rare or common disease, fundamental genetic and genomic mechanisms, technology development, or other major questions in biology and medicine.
Areas of Interest
COMPUTATIONAL GENETICS
- Artificial intelligence, machine learning, statistical genetics, algorithm development, and responsible genomic data science
- Advanced analysis of whole-genome, long-read, single-cell, spatial, multi-omic, proteomic, imaging, biobank, and electronic health record data
- Variant interpretation; genotype–phenotype relationships; population, comparative, structural, functional, and evolutionary genomics
- Knowledge representation, causal and network modeling, data integration, visualization, and scalable software or cloud-enabled systems
EXPERIMENTAL GENETICS & GENOMICS
- Genetic, epigenetic, nucleomic, RNA, protein, metabolic, cellular, developmental, or systems mechanisms in health and disease
- Human genetics integrated with model organisms, organoids, patient-derived systems, iPSCs, transdifferentiated cells, and other innovative platforms
- Functional genomics, single-cell and spatial biology, genome and epigenome engineering, synthetic biology, quantitative phenotyping, and technology development
- Mechanism-driven therapeutic discovery, including gene, RNA, cell, small-molecule, and other precision approaches
Candidates who connect computation and experiment, or who create platforms that enable such integration, are especially encouraged to apply.
Why Baylor Molecular and Human Genetics
- Sustained national leadership in genetics research, with the Department reporting the highest number of NIH grants among genetics departments at U.S. medical schools and average annual NIH funding approaching $75 million over the past decade.
- More than 70 primary research faculty spanning computational genetics, bioinformatics, functional genomics, genome structure and function, disease mechanisms, model systems, and therapeutic development.
- A deeply integrated ecosystem linking fundamental discovery, the Human Genome Sequencing Center, Baylor Genetics, the Medical Genetics Multiomics Laboratory, the Undiagnosed Diseases Center, major disease-focused centers, and one of the country’s largest clinical genetics programs.
- Access to exceptional collaborators and trainees across Baylor, Texas Children’s Hospital, the Jan and Dan Duncan Neurological Research Institute, the Dan L Duncan Comprehensive Cancer Center, Rice University, UTHealth Houston, MD Anderson Cancer Center, the University of Houston, and the broader Texas Medical Center.
An Environment Designed for Discovery and Translation
The Department brings physicians, experimental scientists, quantitative researchers, clinical laboratories, and trainees into a shared genetics and genomics mission. Its research programs span genome sequencing and interpretation, computational and integrative biomedicine, model-organism and precision disease modeling, neurogenetics, cancer, aging, developmental biology, metabolism, genome stability, multiomics diagnostics, gene and genome editing, and clinical investigation. Departmental programs participate in major NIH and industry consortia and support work from fundamental mechanism to diagnostic innovation, preclinical development, and clinical research.
GENOMIC SCALE
Human Genome Sequencing Center; large-scale sequencing, analytical pipelines, clinical-grade genomics, long-read and multi-omic programs.
COMPUTATIONAL DEPTH
Bioinformatics Research Laboratory and Computational and Integrative Biomedical Research Center, with quantitative programs, software engineering, data clinics, and cross-institutional collaborations.
FUNCTIONAL MECHANISM
Cross-species genetics and deeply phenotyped human, mouse, fly, yeast, bacterial, cellular, iPSC, organoid, and other disease models.
CLINICAL TRANSLATION
Baylor Genetics, the Medical Genetics Multiomics Laboratory, the Undiagnosed Diseases Center, rare-disease consortia, specialty clinics, and clinical research infrastructure.
THERAPEUTIC INNOVATION
Genome editing, gene and RNA therapy, preclinical model resources, target discovery, and pathways to clinical investigation and technology transfer.
TRAINING & MENTORSHIP
Genetics and Genomics Ph.D. training, quantitative and interdisciplinary graduate programs, postdoctoral training, medical genetics residencies, and laboratory fellowships.
What We Value
- Original and important questions, methodological rigor, and a clear vision for an independent research program
- A collaborative mindset and the ability to build productive bridges across disciplines, data types, model systems, and clinical domains
- Commitment to excellent mentorship and education
- Professionalism and alignment with Baylor’s values of Respect, Integrity, Innovation, Teamwork, and Excellence
Appointment and Support
Appointments will be made at the Assistant, Associate, or Full Professor level, commensurate with experience and accomplishments. Baylor College of Medicine and the Department offer competitive recruitment packages and resources to launch or expand an outstanding research program. Qualified candidates may also be eligible for recruitment support through the Cancer Prevention and Research Institute of Texas. Additional opportunities may emerge through the Dementia Prevention and Research Institute of Texas.
How to Apply
Submit one PDF containing:
- Curriculum vitae
- A two-page statement summarizing major accomplishments and the vision and priorities for your future research program
Email the application by selecting Apply on website. Arrange for three letters of reference to be sent directly by the recommenders to the same address. Applications will be reviewed on a rolling basis until positions are filled.
Learn More
bcm.edu/genetics | Houston, Texas 77030
Baylor College of Medicine is an Equal Opportunity, Affirmative Action and Equal Access Employer.
As part of the recruitment process, Baylor College of Medicine may conduct reference and background checks, including verification of credentials and degrees and review of professional-misconduct history.
