Offer Description The project The project aims to use several colorectal cancer models developed in the lab to advance in
the understanding of the cellular processes driving metastasis. About the group Our group, Drosophila models of disease and (epi)genetic analysis , located at the Biomedical Research Institute of Lleida (IRBLleida), is interested in understanding the complex choreography of gene expression driving cell plasticity of tumour cells and their adaptation to new microenvironments. We have generated metastatic and non-metastatic models of colorectal cancer in the adult gut of Drosophila based on the induction of the very same mutations involved in human cancer patients in the adult population of intestinal stem cells. We are therefore in a unique position to genetically unravel the mechanisms that initiate metastatic dissemination of primary tumour cells. We have a long-term collaboration with Dr. Kyra Campbell, at the University of Sheffield (UK) and, as part of the PhD training, the student is expected to spend some time in Campbell's laboratory. Requirements Research Field : Biological sciences » Biology Education Level : Undergraduate Skills/Qualifications Applicants should hold a degree in Biology, Biochemistry, Biomedicine or similar with a grade above 6.5 (over 10). Applicants should also have finished a Master degree to qualify for the fellowship. Fluent English skills are also required. Specific Requirements Responsibilities and Tasks Undertake an independent research project under the guidance and supervision of the PI. Successfully complete PhD courses Engage actively in research environments, including a research stint at the University of Sheffield. Contribute to teaching and knowledge dissemination activities. Develop and author scientific papers targeted for publication in high-impact journals. Formulate and defend a comprehensive PhD thesis based on the outcomes and findings of your research project. Languages : ENGLISH Level : Excellent Additional Information Work Location(s) Number of offers available : 1 Company/Institute : Universitat de Lleida Country : Spain State/Province : Lleida City : Lleida Postal Code : 25198 Street : Avinguda Rovira Roure 80 Contact State/Province : Lleida City : Lleida Website : http://www.udl.cat/ Street : Av. Alcalde Rovira Roure, 80 Postal Code : 25198 E-Mail : andreu.casali@udl.cat Phone : 973003758
