The Hellenic College Holy Cross campus in Brookline, Massachusetts, is the institution's sole location, encompassing both Hellenic College for undergraduate liberal arts and Holy Cross Greek Orthodox School of Theology for graduate studies. Situated on a scenic 22-acre hilltop overlooking Boston, it specializes in Orthodox Christian higher education, blending rigorous academics with spiritual and communal formation to develop clergy and lay leaders.
- Theology: Undergraduate major and graduate degrees like MDiv, ThM, DMin, focusing on patristics, liturgy, ecclesiology, pastoral theology, evangelism, and ministry.
- Classics and Greek Studies: Ancient, Byzantine, and modern Greek language, literature, philosophy, and cultural studies.
- Literature and History: Western classics, historical theology, Orthodox historiography, and interdisciplinary humanities.
- Psychology and Human Development: Counseling, pastoral psychology, human behavior, and religious education.
- Business and Nonprofit Leadership: Management, fundraising, organizational leadership for churches and nonprofits.
- Liberal Studies: Core in philosophy, fine arts, education, religion in America, and iconology.
Supporting institutes like the Pappas Patristic Institute advance research, ensuring all programs align with Orthodox tradition while preparing students for contemporary challenges.
