Dr. Jose P. Rizal - National Hero of the Philippines, graduated in 1882, known for his contributions to the Philippine independence movement.
Dr. Camilo Osias - Educator and statesman, graduated in 1905, served as a Senator and was instrumental in the development of the Philippine educational system.
Dr. Conrado Benitez - Educator and author, graduated in 1911, known for his work in educational reform and as a founder of the Philippine Rural Reconstruction Movement.
Dr. Trinidad H. Pardo de Tavera - Physician and historian, graduated in 1881, known for his contributions to Philippine historiography and public health.