The Chennai Main Campus of Sathyabama Institute of Science and Technology serves as the primary hub for a wide array of engineering, science, technology, and health sciences programs. It houses most of the university's schools and departments, emphasizing innovation, research, and interdisciplinary studies in a sprawling 140-acre facility along the IT corridor.
The Sriperumbudur Campus, a modern satellite facility opened to expand access to quality education, focuses primarily on undergraduate programs in arts, sciences, and humanities, particularly computing and emerging technologies. Located in an industrial hub, it supports hands-on learning and industry collaborations for students pursuing tech-oriented careers.