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5.05/4/2026

A true gem in the academic community.

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About Brett

Professor Brett Collins is a leading structural biologist at the University of Queensland's Institute for Molecular Bioscience, where he heads the Molecular Trafficking Lab and directs the Centre for Cell Biology of Chronic Disease. An NHMRC Leadership Fellow, he earned his PhD from Macquarie University in 2001. His career trajectory includes NHMRC Career Development Fellowships from 2006 to 2011 and 2014 to 2017, as well as an Australian Research Council Future Fellowship. Collins has made seminal contributions to understanding membrane trafficking, particularly through high-resolution structural studies of key protein complexes using X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy. His work elucidates how proteins and lipids control endosomal sorting, receptor transport, and organelle homeostasis, with implications for diseases including Alzheimer's, Parkinson's, cancer, inflammation, and pathogen invasion. Notable achievements include defining the molecular architecture of the AP2 clathrin adaptor complex central to endocytosis and pioneering insights into retromer, sorting nexins (SNX), Commander, and cavin proteins in caveola biogenesis.