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Brian Hie is an Assistant Professor of Chemical Engineering at Stanford University, the Dieter Schwarz Foundation Stanford Data Science Faculty Fellow, and an Innovation Investigator at Arc Institute. He supervises the Laboratory of Evolutionary Design, conducting research at the intersection of biology and machine learning. Previously, he was a Stanford Science Fellow in the Stanford University School of Medicine and a Visiting Researcher at Meta AI. He completed his Ph.D. in Electrical Engineering and Computer Science at the Massachusetts Institute of Technology in 2021, along with an M.S. in the same field in 2019, and earned a B.S.H. in Computer Science from Stanford University in 2016.
Hie’s academic appointments include membership in Bio-X, affiliation with the Institute for Human-Centered Artificial Intelligence, and faculty fellowship at Sarafan ChEM-H. His honors include the AI2050 Early Career Fellow from Schmidt Sciences in 2025, Innovation Investigator at Arc Institute in 2024, Stanford Science Fellow in 2021, and National Defense Science and Engineering Graduate Fellowship from the U.S. Department of Defense in 2019. He serves on the Board of Reviewing Editors for Science Magazine since 2025. Key recent publications include “Genome modelling and design across all domains of life with Evo 2” in Nature (2026), “Rapid directed evolution guided by protein language models and epistatic interactions” in Science (2026), and “Semantic design of functional de novo genes from a genomic language model” in Nature (2025). He holds patents related to hyperspectral scanning, private pharmacological collaboration, and escape profiling for therapeutics and vaccines. His work advances predictive and generative models for biological systems, with influence in computational biology and machine learning applications.
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