Rate My Professor Declan O’Regan

Professor Declan O’Regan holds the British Heart Foundation Chair of Cardiovascular AI and is Professor of Imaging Sciences in the Faculty of Medicine at Imperial College London. He is an MRC Investigator leading the Computational Cardiac Imaging Group at the MRC Laboratory of Medical Sciences since 2007. As Consultant Radiologist and Director for Imaging Research at Imperial College Healthcare NHS Trust, he also co-leads the Imperial College BHF Centre of Research Excellence. O’Regan earned his BSc and MBBS from the University of London, DTM&H from the University of Liverpool, and PhD from Imperial College London in 2007. He is a Fellow of the Royal College of Physicians (FRCP) and Royal College of Radiologists (FRCR). His career progression includes Reader in Imaging Sciences (2016-2020), Senior Lecturer (2007-2016), and Schering Research Fellowship (2004-2007) at Imperial College London, alongside specialist training in Clinical Radiology at Hammersmith Hospital.

O’Regan’s research focuses on machine learning to elucidate cardiovascular disease mechanisms by integrating human imaging, genetics, and environmental risk factors. His developments include algorithms predicting survival from cardiac motion and evaluating heart failure risks, alongside industry collaborations for genotype-phenotype modeling in drug discovery. Funded by the Medical Research Council, British Heart Foundation, Heart Research UK, National Institutes of Health, Calico Labs, and Bayer AG, he has authored over 120 peer-reviewed publications in high-impact journals such as Nature and Nature Machine Intelligence. Notable works include “Anatomically constrained neural networks (ACNNs): application to cardiac image enhancement and segmentation” (2017), “Reporting guideline for the early stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI” (2022), and “Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease” (2015). He has served as Roentgen (UK) and Rowan-Williams (Australasia) travelling professor, chairs the Publications Committee of the Society of Cardiac MR, was Associate Editor for European Heart Journal - Cardiovascular Imaging and npg Digital Medicine, and is Guest Editor for Circulation. O’Regan contributes to the MRC Clinical Training and Career Development Panel and BHF Advisory Council.