Rate My Professor Diane Bimczok

Her research examines the interplay between pathogens, mucosal antigen-presenting cells including dendritic cells and macrophages, and epithelial cells at mucosal surfaces, with the aim of understanding how epithelial responses to bacteria and viruses influence infection outcomes and antigen-presenting cell function. Current projects focus on Helicobacter pylori infection in the human gastric mucosa using gastric organoid and spheroid models, SARS-CoV-2 infection in human and bat intestinal organoids, and Mycoplasma ovipneumoniae pathogenesis in sheep. She utilizes innovative models such as the Gastrointestinal Organoid Flow Chip (GOFlowChip) developed in collaboration with engineering and microbiology colleagues, alongside primary mucosal cells, tissue explants, large animal models, and transgenic mice. Funded by the NIH and USDA, her laboratory has produced key publications such as "Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection" (Journal of Virology, 2009), "Inflammation anergy in human intestinal macrophages is due to Smad-induced IκBα expression and NF-κB inactivation" (Journal of Biological Chemistry, 2010), "Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori–infected children" (Mucosal Immunology, 2013), and "Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection" (Nature Communications, 2023). With over 2,100 citations, her work significantly impacts the understanding of mucosal immune responses and host-pathogen dynamics.