Rate My Professor Guoping Fan

Guoping Fan is a Full Professor at the School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong. He obtained a BSc degree in Biochemistry from Nanjing University and a PhD in Neurosciences from Case Western Reserve University, USA. Following postdoctoral training at the Whitehead Institute for Biomedical Research/MIT completed in 2001, he was appointed faculty in the Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), rising to full Professor in 2011 and Professor Emeritus since 2021. He also held positions as Distinguished Adjunct Professor at ShanghaiTech University from 2019 to 2024 and Adjunct Professor at Scintillon Research Institute in San Diego, California, from 2024.

Professor Fan's academic interests center on epigenetic studies of DNA methylation in development and disease, animal models of human diseases, stem cell technology focusing on neural cell differentiation and organoids, and mRNA delivery technology for rare diseases. He has published over 120 original papers, reviews, and book chapters, accumulating more than 25,000 citations. Select key publications include "DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation" (Molecular Cell, 2025), "Tuning up gene transcription via direct crosstalk of DNA and RNA methylation" (Molecular Cell, 2025), "Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids" (Nature Communications, 2024), "Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation" (Nature Communications, 2023), and "Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging" (Cell Stem Cell, 2021). His achievements include awards such as Basil O’Connor Scholar, Carol Moss Spivak Scholar in Neuroscience, Royan International Research Award in Embryology, and First Prize Award in Science and Technology from the Chinese Medical Society. Professor Fan has reviewed grants for NIH, U.S. states, European countries, and the Natural Science Foundation of China, and has served as a board member of the Chinese Society of Stem Cell Research since 2021.