Rate My Professor Jane Davies

Professor Jane Davies is Professor of Paediatric Respirology & Experimental Medicine at the National Heart and Lung Institute, Faculty of Medicine, Imperial College London, and an Honorary Consultant in Paediatric Respiratory Medicine at the Royal Brompton & Harefield NHS Foundation Trust. She graduated with an MB ChB from the University of Dundee in 1987, obtained MRCP (Paeds) in 1991 and MRCPCH in 1996 in London, and earned an MD (Hons) from the University of Dundee in 1998. Her career began in 1989 with Senior House Officer positions in paediatrics at various London hospitals, including West Middlesex, Great Ormond Street, and Queen Elizabeth for Children. She pursued specialization in paediatric respiratory medicine and intensive care at the Royal Brompton Hospital from 1992 to 1994, followed by a Research Fellowship in Paediatric Cystic Fibrosis there from 1994 to 1997. Subsequent Specialist Registrar training led to her appointment as Senior Lecturer in Gene Therapy at Imperial College London in 1999, promotion to Reader in 2009, and Professor in 2013.

Jane Davies specializes in cystic fibrosis research, with interests in novel therapies, clinical trial design, outcome measures for lung disease in young children, Pseudomonas aeruginosa pathogenesis and antimicrobial therapies, innate defence, airway remodelling, and inflammation. As principal investigator, she has led key phase 3 trials for CFTR modulators, such as ivacaftor for G551D patients (NEJM, 2011), lumacaftor-ivacaftor for F508del homozygotes (NEJM, 2015), VX-659/tezacaftor-ivacaftor (NEJM, 2018), and elexacaftor/tezacaftor/ivacaftor in children (AJRCCM, 2021-2022). These have profoundly impacted CF treatment, benefiting approximately 90% of patients. Her accolades include the NIHR Senior Investigator Award (2020), European Respiratory Society Fellowship (2018), Imperial College Rector’s Gold Medal (2014), NIHR awards for trials leadership (2016) and outstanding PI (2019), Talamo Lecturer (2019), 2023 Royal College of Physicians Croonian Lecture, and OBE (2024) for services to cystic fibrosis research.