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Ryan Julian serves as Professor of Chemistry in the Department of Chemistry at the University of California, Riverside. He earned a B.S. degree from the University of Utah in 1999 and a Ph.D. from the California Institute of Technology in 2003. His academic career at the University of California, Riverside includes progression through the faculty ranks to his current position as full professor.
Julian's research centers on mass spectrometry applications to investigate protein structure, modifications, and isomers in peptides and proteins. His work addresses topics including aging, long-lived proteins, and protein structure and modifications. Recent studies have examined the competition between amyloid beta and tau proteins for binding sites on microtubules in the context of Alzheimer's disease. Additional contributions include the development of a method for selectively cleaving intact proteins in the gas phase, with initial findings published in the Journal of the American Chemical Society, and investigations into tau isomerization in Alzheimer's disease along with mechanistic studies of peptide radicals. He maintains an active laboratory focused on these areas of chemical biology and analytical chemistry.
A new University of California Riverside study uncovers how key Alzheimer’s proteins amyloid beta and tau compete for microtubule binding sites inside brain cells, reshaping our understanding of disease onset and opening doors to novel therapies.
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