Rate My Professor Jernej Murn

The Murn Lab investigates the central role of RNA in biology, with a focus on RNA-binding proteins (RBPs) that regulate gene expression, RNA processing, cellular quiescence, neuronal function, aging, and diseases including cancer and neurological disorders. Employing genome-wide and computational approaches combined with biochemistry, genetics, and cell biology, the lab aims for a systems-level understanding of RNA networks and develops novel technologies to decipher in vivo protein-RNA and RNA-RNA interactions. Key publications include 'Composition and RNA binding specificity of metazoan RNase MRP' (Nucleic Acids Research, 2025), 'Cellular quiescence induced by rapid depletion of RNase MRP' (Nature Communications, 2025), 'A pseudouridine-binding protein' (Journal of the American Chemical Society, 2025), 'A paradigm for regulation at the effector interface with RNA-binding proteins' (Nature Communications, 2024), and 'Post-translational modulation of RNA-binding proteins' (Journal of Biological Chemistry, 2023). Murn co-led a study on genome organization influencing cell fate and has contributed to research on histone chaperones coupled to DNA replication and transcriptional regulation.