Advancing Functional MRS: Methodological Development for Dynamic Neurochemical Measurement

Project Overview

Functional magnetic resonance spectroscopy (fMRS) is an emerging neuroimaging approach that measures rapid, task-evoked changes in brain metabolites. Unlike traditional MRS, which provides a static snapshot of neurochemical composition, fMRS offers a unique window into dynamic neurochemical processes such as glutamate responses to sensory, cognitive, or emotional stimulation. This makes fMRS a powerful complement to established techniques like functional magnetic resonance imaging (fMRI), providing direct insight into neuronal function.

Project Aim

This PhD will develop and evaluate robust experimental and analytical frameworks for fMRS. Although fMRI methodology is well established, equivalent standards for fMRS remain underdeveloped. Experimental design choices (including task structure, timing, acquisition parameters, and analysis pipelines) have a profound impact on the reliability and interpretability of fMRS data. Establishing best-practice paradigms is essential for advancing the field.

Research Objectives

The student will:

• Optimise fMRS experimental designs to maximise sensitivity to dynamic metabolite changes
• Develop and evaluate analysis pipelines beyond conventional approaches
• Assess reproducibility and robustness across tasks, acquisition strategies, and quantification methods
• Contribute methodological insights that will shape future fMRS research

Training and Development

You will receive comprehensive training in advanced MRS and fMRS acquisition techniques, MRS quantification and modelling, programming for neuroimaging analysis (e.g., MATLAB), experimental design and reproducible research practices.