"Assistant Professor"

Assistant Professor

University of Colorado Anschutz Medical Campus

Department of Pediatrics | Section of Neonatology

Job Title: Assistant Professor

Position #: 00845870 - Requisition #:39285

Job Summary:

The Department of Pediatrics, Section of Neonatology has an opening for a full-time Assistant Professor, PhD (Fetal Physiologist and Molecular Biologist) at the Perinatal Research Center on the Anschutz Medical Campus working in the laboratory of Dr. Laura Brown, MD. The Perinatal Research Center provides multi-disciplinary basic and translational research in the areas of perinatal biology and medicine. The Brown laboratory within the PRC focuses on impact of adverse events in pregnancy, namely intrauterine growth restriction, on fetal skeletal and cardiac muscle growth and development. The Assistant Professor role is responsible for many assays related to the assessment of skeletal muscle growth and function, including muscle harvest, tissue processing, molecular analysis of protein and RNA, histological analysis, mitochondrial function, and the capacity for cell growth and differentiation in culture. It also requires experience in fetal surgery for indwelling catheter placement in animal models of IUGR, including sheep and mouse.

Key Responsibilities:

• Independently performs live animal surgeries in pregnant sheep for the placement of indwelling maternal and fetal catheters, flow probes, and muscle biopsies - 20%
• Performs tissue and cell harvest and preserve samples for cell culture, single cell isolations, histology, protein and RNA analyses - 20%
• Performs myofiber incubations with a variety of growth stimulators, inhibitors, and tracers to estimate protein kinetic rates - 10%
• Figure preparation using Power Point and manuscript preparation and proofreading - 10%
• Performs histological procedures, including cryosectioning and complex immunohistochemical staining and demonstrates a highly technical capacity in the utilization of laboratory equipment and reagents - 10%
• Oversees student trainees (residents, fellows, students) in the laboratory, provides teaching and oversight for laboratory assays and techniques - 10%
• Performs statistical analyses of large and small data sets including metabolomic and proteomic data sets and has an excellent fund of knowledge about different statistical approaches - 10%
• Organizes and maintains all current and archived specimens and data - 5%
• Maintains and evaluates quality control/assurance metrics and review laboratory documents for accuracy and completeness in agreement with Standard Operating Procedures (SOPs), Good Laboratory Practices (GLPs) and study specific requirements - 2%
• Completes all UCD required training and compliance courses - 2%
• Performs other duties as assigned - 1%

Work Location: Onsite - this role is expected to work onsite and is located in Aurora, CO.

Qualifications:

Minimum Qualifications:

• Doctor of Philosophy (PhD) in Biology, Biochemistry, Chemistry, or Animal Sciences
• A minimum of 6 years of experience as a postdoctoral fellow within an academic, medical, or related research laboratory environment.
• Experience (5 years) performing live animal surgeries in pregnant sheep independently for the placement of indwelling catheters, flow probes, and muscle biopsies in the fetus
• Experience (5 years) harvesting both skeletal myocytes and cardiomyocytes for single cell isolations and for propagation in cell culture
• Experience (5 years) performing large analysis of metabolomic data, preparation of heat maps, PCA plots, pathway analysis and statistical analysis.

Preferred Qualifications:

• Experience with complex metabolomic and transcriptomic analyses
• Experience working with a diversity tissue types
• Experience working with network-based software systems for data management

Knowledge, Skills and Abilities:

• Ability to accurately follow assigned protocols and develop new techniques as needed.
• Demonstrates capacity to work independently and trouble shoot complex processes.
• Demonstrates organizational, methodical, detail-oriented, self-motivated competencies.
• High emotional quotient (EQ) with the ability to effectively communicate and function as a member of a multi-disciplined, cross-functional progressive research unit.
• Lift, push and/or pull up to 20 pounds.
• The position may also require a stationary position and movement for extended periods, along with the ability to execute repetitive motions, as required during the provision of services.
• Work in an environment that may expose you to fumes, chemicals, liquid nitrogen, extreme cold, blood and body fluids, infectious disease, radioisotopes and other biohazards.
• Work with complex technology and laboratory equipment, various chemical and biological solutions, and wear all PPE as appropriate.
• Work within a high-level secured facility.

Anticipated Pay Range: HIRING RANGE: $95,000