"Doctoral Researchers in structural biology/parasitology, group Muhleip"

The HiLIFE - Institute of Biotechnology at the University of Helsinki is excited to announce two positions for Doctoral Researchers to join the group of Dr. Alexander Mühleip.

Project Description

The research in the group is focused on understanding how protein complexes organise mitochondrial membranes in protozoan parasites and how membrane organization is disrupted in human mitochondrial disorders. The successful applicant will work on the structural and functional characterisation of mitochondrial energy conversion complexes and remodelling in protozoan parasites using protein biochemistry, single-particle cryo-EM and in-situ cryo-electron tomography. Specifically, the project is aimed at visualisation of inner-membrane architecture and characterising parasite-specific modulation of membrane biogenesis. The project offers the unique opportunity to combine parasitology and mitochondrial biology with state-of-the-art structural biology techniques. The group benefits from in-house availability of a 200-kV Talos Arctica microscope, complemented by access to 300-kV cryo-electron microscopes for data collection at international facilities.

Recent publications from the group:

• https://www.nature.com/articles/s41594-025-01531-7
• https://www.nature.com/articles/s41467-025-56057-9

About you

• You are ambitious, goal-oriented, collegial and motivated to tackle a challenging project.
• High interest in learning structural biology methods (comprehensive cryo-EM training will be provided), previous experience is beneficial.
• Prior experience in parasitology cell culture work and genetic engineering (malaria or kinetoplastid parasites) is greatly beneficial but not required.
• Master’s degree (or be in the final stages obtaining degree) in cell/molecular biology, parasitology, protein biochemistry, structural biology or a similar field.
• Excellent command of English (working language at the institute).
• Strong communication, interpersonal, organizational and time management skills.

What we offer

• A collaborative, innovative and inclusive work environment.
• Training in state-of-the-art methods in structural parasitology.
• Doctoral education within the Integrated Life Sciences Doctoral programme (ILS): https://www.helsinki.fi/en/admissions-and-education/apply-doctoral-programmes/doctoral-school-and-doctoral-programmes/doctoral-programmes-health-sciences/doctoral-programme-integrative-life-science
• A competitive salary depending on your qualifications and personal performance, 5-7 weeks of holiday, flexible working hours.
• Occupational health care and access to high-quality sports facilities.

How to apply?

Welcome with your application in English as soon as possible or no later than 30th September 2025. Please note that applications will be continually reviewed. The positions are available immediately or according to mutual agreement. Applications should include a cover letter, CV, and contact details of three references. For further information on the position, please contact Alexander Mühleip (alexander.muhleip@helsinki.fi).About the Institute of Biotechnology, HiLIFE, University of Helsinki

The Institute of Biotechnology is an independent research institute within the University of Helsinki Institute of Life Science (HiLIFE), at the University of Helsinki, Finland, and at the global forefront of life science research with state-of-the-art research core facilities in genomics, biological imaging and structural biology. According to the 2024 Times Higher Education World University survey, the University of Helsinki is ranked among the top 80 universities world-wide in life science research. The University of Helsinki is committed to providing a welcoming environment for international researchers, offering comprehensive services and support for relocating to Finland—a country known for its high quality of life, excellent education system, and robust support for research and innovation.