Elucidating the Immunomodulatory Role of NME4 in Macrophage and Neutrophil Responses using Zebrafish (Danio rerio)

About the Project

Mitochondria are not only the powerhouses of the cell but also key regulators of innate immunity, influencing processes such as inflammasome activation, reactive oxygen species (ROS) production, and metabolic reprogramming.

NME4, also known as nucleoside diphosphate kinase D (NDPK-D) or NM23-H4, is a mitochondrial enzyme that plays a pivotal role in linking mitochondrial homeostasis to innate immune signalling. This PhD project proposes to explore NME4’s dual functions in nucleotide metabolism and mitochondrial dynamics, and how these mechanisms regulate innate immune signalling in response to microbial threats such as lipopolysaccharide (LPS).

By employing genetic knockout models, advanced imaging, and metabolic profiling, the project aims to uncover novel therapeutic targets for inflammatory diseases like sepsis. The research will span cellular, molecular, and in vivo studies in model organisms, contributing to our understanding of mitochondria as central hubs in immunity.

Entry Requirements:

Applicants should normally have at least a first class or an upper second-class UK Bachelors Honours degree (or equivalent) in an appropriate discipline.

Applicants whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study. For more information, please see the University page on English Language requirements for Postgraduate courses: https://sheffield.ac.uk/postgraduate/english-language

Proposed start date: 01 October 2026

How to apply:

Please complete a University Postgraduate Research Application form available here:http://www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select (School of Medicine) as the department.

Enquiries:

Interested candidates should in the first instance contact - Richmond Muimo (r.muimo@sheffield.ac.uk)

Funding Notes

This project is open to applicants who have the funding to support their own studies or who have a sponsor who will cover these costs.

This project is for four years, so will require four years of tuition fees and will require an additional £15,000 per year to run the project.

This is open to both home and overseas applicants.