system starts to attack healthy cells, a phenomenon referred to as autoimmunity. The biochemical pathways underpinning autoimmunity remain poorly understood, making the resulting medical conditions particularly challenging to diagnose and treat. This project aims to unpick the GBP-glycan interactions which underpin these complicated but fascinating diseases, with a view to improving patient outcomes.

This project will apply a range of chemical biology and biophysical techniques to better understand autoimmune protein-glycan interactions. The primary focus will be on developing biological mass spectrometry methods to directly measure and characterise these interactions. The student will apply these workflows to a range of biological systems, including purified proteins, cellular models, and human biofluids, to study GBP-glycan interactions across different medically relevant contexts. As such, the student will benefit from training across a variety of techniques and areas, with the project having scope for scientific expansion in line with their own research interests.

The ideal candidate for this role has a strong interest in biological chemistry and mass spectrometry. Typical experience would be an MChem degree or equivalent in chemistry or biochemistry (or comparable experience). Effective written and verbal communication skills, good time-management and the ability to work in a collaborative environment are essential.

system starts to attack healthy cells, a phenomenon referred to as autoimmunity. The biochemical pathways underpinning autoimmunity remain poorly understood, making the resulting medical conditions particularly challenging to diagnose and treat. This project aims to unpick the GBP-glycan interactions which underpin these complicated but fascinating diseases, with a view to improving patient outcomes.

This project will apply a range of chemical biology and biophysical techniques to better understand autoimmune protein-glycan interactions. The primary focus will be on developing biological mass spectrometry methods to directly measure and characterise these interactions. The student will apply these workflows to a range of biological systems, including purified proteins, cellular models, and human biofluids, to study GBP-glycan interactions across different medically relevant contexts. As such, the student will benefit from training across a variety of techniques and areas, with the project having scope for scientific expansion in line with their own research interests.

The ideal candidate for this role has a strong interest in biological chemistry and mass spectrometry. Typical experience would be an MChem degree or equivalent in chemistry or biochemistry (or comparable experience). Effective written and verbal communication skills, good time-management and the ability to work in a collaborative environment are essential.