MRC Postdoctoral Research Scientist LMS 2743

MRC Laboratory of Medical Sciences – Chromatin and Development

About us

The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS is one of three directly funded MRC research institutes and enjoys close links with our partners at Imperial College London and the Imperial College Healthcare NHS Trust.

About the role

We are seeking an enthusiastic and reliable Postdoctoral Researcher to join the Chromatin and Development group and support 1-2 projects during maternity leave and paper revisions. These projects cover the exciting topics of metabolism and epigenetic regulation of early mouse development and chromatin biology. The ideal candidate will be a talented bench scientist who is collaborative and keen to lead and contribute to some important pieces of work within the lab. This position would suit someone looking for a short-term postdoc and the chance to work on 1-2 papers. Alternatively, depending on CV and success, the candidate will be supported to apply for external funding to continue a longer postdoc in the lab and continue the work.

About you

The ideal candidate will have a PhD (or equivalent experience) in gene regulation, chromatin biology, development or a related biological field. Prior experience of embryonic stem cell (ESC) culture and/or mouse embryology is highly desirable, as is experience with techniques in gene and chromatin regulation such as CRISPR, Cut&Tag, Cut&Run, ATAC-seq. One project focuses on determining the mechanistic link between metabolite compartmentalization and mouse ESC chromatin and cell fate. The second project involves regulation of chromatin reprogramming in early mouse embryos. Ideally, a candidate would have the experience and/or skills to contribute to both projects; however only one is essential. The position is available to be filled January 2026. Owing to the recruitment time, it is unlikely sponsorship of a visa is possible.

What we offer

As well as the exciting opportunities this role presents, we also offer defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits

How to apply

For full details of this post and to complete an online application, click the 'Apply' button above and upload your CV, names and contacts of two scientific references along with a cover letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be accepted. Please quote reference number LMS 2743

*Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two which will be adjusted accordingly.

Closing date: 2 December 2025

***Final appointment will be subject to pre-employment screening***

**Please note that applications may be reviewed by both LMS and Imperial staff**