MSc by Research: Bacillus subtilis intraspecies interactions

About the Project

Interbacterial competition is ubiquitous and plays a key role in shaping diverse microbial communities, including the gut microbiota and in the rhizosphere. Bacteria normally exist within mixed microbial populations and must be able to compete effectively for space and nutrients to enter and survive within these communities.

Bacillus subtilis is a Gram-positive, spore-forming bacterium that resides in intestinal tracts, soil, and on plant surfaces. B. subtilis, alongside other Bacillus species, presents a promising plant growth–promoting rhizobacteria.……We predict that a clear understanding of B. subtilis intraspecies competition will allow us to better select plant growth-promoting strains that can outcompete existing B. subtilis isolates that already reside in the environment.

Polymorphic toxin systems (PTS) are a hallmark of bacterial competition. These systems can transport toxic proteins with polymorphic C-terminal domains into nearby bacteria. Targeted cells that lack the intracellular cognate antitoxin (immunity) protein are killed or have their growth inhibited. B. subtilis has been found to utilize multiple differing PTS to mediate intraspecies antagonism. The aim of this project is to use molecular biology coupled with bioinformatics and biochemistry to further our understanding of these antagonistic interactions.

Alongside developing your laboratory skills, you will be given training in data management and presentation skills and will be provided ample opportunities to develop other professional skills that you wish to enhance.

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.