MSc by Research: Investigation of mitochondrial biology and neurodegeneration

About the Project

Phosphorylation and ubiquitylation are reversible signalling events and there is significant interest in in their interplay in the regulation of normal biological processes and disruption in human diseases. Previous research in our lab has defined a role of the PINK1 kinase and Parkin ubiquitin ligase in sensing mitochondrial damage and eliminating damaged mitochondria by autophagy (mitophagy). How the pathway is regulated by other mitochondrial proteins is of interest. However, a major challenge in studying mitochondrial protein biology is that many mitochondrial proteins are essential limiting the ability to generate knockout cell types. The project will employ CRISPR/Cas9 genome editing technology and PROTAC approaches to chemically degrade candidate PINK1 regulator proteins. These studies will lead to greater understanding on how PINK1 is regulated that will be of relevance for Parkinson’s disease mechanisms.

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.

Please see our website for further details on the programme and how to apply: Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

When you complete your application form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application, please note our intake deadlines on the ‘how to apply’ section of our website.