Post Doc Fellow, Zhang Lab, UC College of Medicine, Department of Cancer Biology

Job Overview

As one of the oldest medical schools in the country, the UC College of Medicine has a reputation for training best-in-class healthcare professionals and developing cutting-edge procedures and research that improve the health and clinical care of patients.

The Department of Cancer Biology at the University of Cincinnati has an opening for a Postdoctoral Fellow supported by NCI R01 grants to study transcriptional and epigenetic gene regulation in breast cancer metastasis and therapeutic resistance. The Zhang laboratory (https://med.uc.edu/zhanglab) currently focuses on elucidating the role and molecular mechanisms of gene- and tissue-specific transcriptional cofactors and small RNAs in liquid-liquid phase separation (LLPS) and the above processes [Estrogen Receptor and Breast Cancer ? Celebrating the 60th Anniversary of the Discovery of ER (1st ed, 2019, Springer Nature*), Cell Reports (2021) 34(10):108822, Dev Cell (2021) 56(3):341, Cancer Drug Resist (2022) 5(2): 498, Cancers (2024) 16(23):3992]. We are using a combination of biochemical, molecular, genomic, and mouse genetic (conditional knockout, mutant knocking, and overexpression) approaches. We are also currently developing RNA-based nano-therapeutics to target these cofactors and small RNAs to overcome the therapeutic resistance of human breast cancer.

Essential Functions

• Conduct research experiments in a particular field within the pre-determined research scope and methodology.
• Gather and analyze data and develop new ideas that promote current research.
• Prepare data summaries, reports, manuscripts and presentations of research results.
• Participate/assist in manuscript writing for publication in scientific journals and/or presentation; may assist in grant writing.
• Keep informed of developments in the field to maintain and enhance professional expertise.
• Lab maintenance, including equipment maintenance and ordering of supplies, as needed.
• May teach techniques to others, train, and mentor junior research staff.
• Engage in appropriate training and professional development opportunities.
• Play an active role in seeking career and research advice, both from the faculty supervisor and from other faculty members as well.
• Perform related duties based on departmental need. This job description can be changed at any time.

Required Education

Doctoral Degree in Molecular and Cellular Cancer Biology, Biochemistry, or a related field.

Additional Qualifications Considered

Prior experience with Cancer Biology, Animal Models, RNA Splicing or LLPS Biochemistry is ideal.

Physical Requirements/Work Environment

• Office environment/no specific unusual physical or environmental demands.