Post Doc

Essential Job Duties

The Saini Lab focuses on lungs and liver toxicology. We develop and evaluate the mouse models of lung and liver injury through extensive histological and molecular techniques. The recruited candidate will conduct research on the NIH-funded models of liver inflammation.

Duties and Responsibilities

• Develop transgenic mouse models of liver injury using Cre-LoxP and/or CRISPR/Cas9 system.
• Establish in vitro human models (spheroid/organoid) of liver injury.
• Evaluate the functions of Tristetraprolin family of RNA-binding proteins in MASLD/MASH and hepatocellular carcinoma
• Collaborate within and outside laboratory to execute research projects on liver biology.
• Prepare peer-reviewed publications and grant proposals.

Other Work/Responsibilities

n/a

Department Required Skills

• Experience in generating transgenic mice.
• Experience in characterization and validation of experimental disease in mice models.
• Practical experience in general molecular biology techniques as well as tissue processing, sectioning, and histological staining.
• Evidence of original publications in peer-reviewed literature.
• Good communication and ability to work independently or in collaboration.

Preferred Years Experience, Skills, Training, Education

Previous experience with transgenic mouse models of liver disease is highly considered. Background in liver in vivo, in vitro assays, and bioinformatics are key assets.
PhD in Biomedical Sciences, Immunology, Toxicology, or relevant field