"Postdoc Regulation of Membrane Synthesis by Enzyme Filamentation"

Job Summary: We seek a highly motivated individual to identify the structural mechanism by which bacteria coordinate membrane synthesis with growth. The role involves studying how cells control membrane content in E. coli, using live-cell imaging and enzyme filamentation to regulate phospholipid synthesis. This project is part of the EVOLF consortium aiming to create living cells from nonliving materials.

Responsibilities: Use electron microscopy to determine the molecular structure of protein filaments; design mutants unable to form filaments; test hypotheses on feedback-resistant enzymes; integrate synthetic pathways with elements like cell division machinery; collaborate with the Bokinsky Lab and Jakobi Lab on synthetic biology and membrane metabolism research.

Qualifications and Requirements: Applicants should have or be about to earn a PhD in structural biology, biochemistry, biotechnology, biophysics, microbiology, or a related field. Experience with peripheral membrane protein purification, cryo-electron microscopy, super-resolution microscopy, or liquid chromatography/mass spectrometry is desirable. Excellent written and spoken English skills are required.

What the Employer Offers: A 2.5-year contract for 36-40 hours per week at TU Delft. Salary and benefits in accordance with the Collective Labour Agreement for Dutch Universities, including a customizable compensation package, discounts on health insurance, monthly work costs contribution, and flexible work schedules. Support for relocation, including events and a Dual Career Programme.