Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

To learn more about us, click here.

About the role

We are looking for a Postdoctoral Fellow to join the C Swanton Cancer Laboratory. This lab studies how cancers evolve in the body to spread and become resistant to therapy and find new ways to treat them more effectively.

Please click here for more information on the lab

Lung cancer remains one of the most pressing public health concerns worldwide. Our research presents two distinct yet intertwined project directions:

Firstly, we are committed to advancing our understanding the biology of lung tumour evolution based around analysis of next generation sequence (NGS) data and the tumour microenvironment from the TRACERx longitudinal lung cancer program. Our aim is to trace the intricate evolutionary trajectories of lung tumours across space and time.

Our second research direction investigates the role of non-mutagenic carcinogens in lung cancer initiation. We aspire to identify actionable targets within these pathways suitable for therapeutic intervention to prevent the onset of cancer.

What you will be doing

You will:

• Work within the multi-disciplinary team of clinicians, bioinformaticians and bench scientists in the Swanton lab, and across Francis Crick Institute
• Attending and reporting research results at group meetings
• Contributing to the dissemination of scientific results by writing papers for publication and presenting orally and in poster form at national and international meetings

Please see full job description

About you

You will have

• PhD, or in the final stages of PhD completion in cancer biology / evolutionary biology / cancer immunology / genomics or relevant discipline*
• Good knowledge and experience in at least one of the following: cancer biology / cancer immunology / epithelial cell biology / evolutionary biology / genomics / statistics / mathematics or machine learning*
• Technical qualifications:
  • For bench scientist: expertise in mouse models of cancer, functional in vitro assays, experience with alveolar Type 2 organoid cell culture, experience with tissue histology/ flow cytometry methods, familiarity with CRISPR/Cas9 or other genetic perturbation approaches*
  • For computational scientist: previous experience with NGS data analysis; fluency in R, Python or C++
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals*

Minimum Criteria*

Working at the Crick

Our values

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
• We are collegial. We show respect for one another, work cooperatively and support the wider community.

At the Crick, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. If you need assistance with your application, please contact karen.au@crick.ac.uk

To read about our EDI approach, click here.

To read about benefits we offer click here.

Please apply via the ‘Apply’ button above.