"Postdoctoral position in Immunology"

Postdoctoral position in Immunology

Location: University of Pennsylvania

Open Date: Jan 13, 2026

The Locci lab studies T cell-B cell collaborations in health and disease (www.loccilab.com). Areas of active investigation in the lab include T follicular helper (Tfh) cell differentiation and regulation of B cell responses in vaccination, infection, and autoimmunity in mice and humans. The Lab is part of the Institute for Immunology and Immune Health (I3H), a large and vibrant immunology community at the University of Pennsylvania (Philadelphia, USA).

We are seeking a motivated and talented postdoctoral researcher to lead a project aimed at dissecting the mechanism of Tfh cell and germinal center induction by mRNA-LNP vaccines. Qualified applicants should hold a PhD or an MD, possess a strong background in immunology, and have experience with in vivo mouse work, high-parameter flow cytometry, and confocal microscopy. Previous experience with mass spectrometry and bioinformatic skills is highly desirable.

Publications highlighting previous work from our group are:

• Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses. Castano, Bettini et al. Cell 2025
• Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Lederer et al. Cell 2022
• Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Alameh et al Immunity 2021

Applicants should submit a curriculum vitae, a cover letter, and contact info for two references.

Foreign national postdocs are eligible to apply.

Qualifications

Qualified applicants should hold a PhD or an MD, possess a strong background in immunology, and have experience with in vivo mouse work, high-parameter flow cytometry, and confocal microscopy. Previous experience with mass spectrometry and bioinformatic skills is highly desirable.

Application Instructions

Applicants should submit a curriculum vitae, a cover letter, and contact info for two references.

To apply, visit https://apply.interfolio.com/180070