Postdoctoral Research Associate in vascular cell plasticity and translation (single-cell and omics) (Fixed Term)

We invite applicants for a postdoc position (Research Associate) for a project in Dr Helle Jorgensen's group in the Heart and Lung Research Institute at the University of Cambridge.

The Jorgensen group studies regulation of cell plasticity and heterogeneity in vascular diseases, such as atherosclerosis. We have demonstrated extensive transcriptional and functional heterogeneity of smooth muscle cells and identified regulatory mechanisms relevant for disease. The group studies mechanisms underlying disease, by combining computational analysis of large datasets with functional analyses in a collaborative environment. Examples of our work include Chappell 2016, Circ Res; Dobnikar/Taylor 2018, Nat Comms, Lambert/Oc 2024, Nat CVR; Taylor 2025, CVR.

We are now seeking a highly talented and motivated individual to join our team. The project is an international collaboration that combines computational analysis of large datasets from humans with mechanistic and functional analysis using both in vitro and in vivo disease models. The role will also include opportunities for contribution to translational projects.

The ideal candidate will be comfortable with both computational data analysis and experimental research. A strong background in computational data analysis of omics data is required. Expertise in molecular and cell biology and/or in vivo vascular disease models is desirable. Knowledge of gene regulation, control of cell state and cardiovascular biology would be an advantage but is not essential.

Essential skills:

• PhD degree, or submitted thesis, in a relevant area (e.g. biological science or a numeric discipline with experience in experimental research)
• Conceptual understanding of transcriptomics and functional genomics, ideally using single cell technologies
• Knowledge of R and/or Python for analysis of large datasets
• Interest in cardiovascular biology
• Ability to plan and manage research projects
• Proactive attitude and drive
• Strong communication skills and the ability to work effectively in teamwork
• Attention to detail and ability to multi-task
• Experience in writing scientific manuscripts and reports
• Effective presentation skills

Desirable skills:

• Knowledge of cardiovascular biology
• Strong publication record
• Molecular and cell biology expertise
• Expertise in culturing primary cells and establishing functional assays
• Experience with animal models
• UK Home Office Personal Licence

Informal enquiries are welcome and can be directed to Dr Helle Jorgensen at hfj22@cam.ac.uk.

Fixed Term: This position is available until 30th September 2027, in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,610) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference RC48311 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Apply online

Key information

Department/location

Department of Medicine

Salary

£37,694-£46,049

Reference

RC48311

Category

Research

Date published

16 December 2025

Closing date

13 January 2026