Position Summary

A postdoctoral position (Ph.D. or M.D./Ph.D.) is available in the laboratory of Dr. Sadaf Amin at WashU Medicine in St. Louis to investigate innate immune pathways in neurodegenerative diseases and brain aging.

The Amin Lab studies the role of neuro-immune interactions in the pathogenesis of neurodegeneration and age-related brain disorders. We are an enthusiastic and collaborative team seeking a highly motivated individual to join our new and growing research group.

Projects are available to (1) study immune“RNA crosstalk in neurodegeneration to decipher the role of maladaptive innate immune pathways in neuronal stress and death, and (2) examine how mito-nuclear retrograde signaling contributes to microglial dysfunction and senescence in Alzheimer’s disease and related dementias. We use a combination of iPSC-based systems and transgenic mouse models coupled with novel approaches including single-cell sequencing, CRISPR“Cas9 screening, and interactome profiling. The work will contribute to our overall goal of advancing novel therapeutic targets for neurodegenerative disease.

Candidates with backgrounds in computational biology, stem cell biology, or neuroscience are strongly encouraged to apply.

Job Description

Primary Duties & Responsibilities:

Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.

A background on our research can be found by reading some of our recent papers at https://sites.wustl.edu/aminlab/.

Trains under the supervision of a faculty mentor including (but not limited to):

• Assists with grant preparation and reporting.
• Prepares and submits papers on research.
• Assists in the design of research experiments.
• Evaluates research findings and assists in the reporting of the results.
• Conscientious discharge of their research responsibilities.
• Maintains conformity with ethical standards in research.
• Maintains compliance with good laboratory practice including the maintenance of adequate research records.
• Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
• Collegial conduct towards co-trainees, staff members and members of the research group.
• Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Working Conditions:

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range:

Base pay is commensurate with experience.

Applicant Special Instructions:

Interested candidates should submit a cover letter, CV, and 3 letters of recommendation to Sadaf Amin at amins@wustl.edu.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

Preferred Qualifications:

• A Ph.D. or M.D./Ph.D. in neuroscience, computational biology, cell and developmental biology, or a related discipline involving the interrogation of cellular pathways using in vitro platforms and ˜omics’ datasets.
• Prior experience with iPSC-based culture techniques and in vitro disease modeling (highly beneficial).
• Familiarity with transgenic mouse models and proper mouse handling techniques.
• Skills in at least one programming language (R, or Python) are strongly preferred.
• Proficiency in conducting or analyzing single-nucleus RNA sequencing data and experience with Seurat or similar gene-based association tools is encouraged.