Postdoctoral Research Fellow

PRIMARY DETAIL

Join a world-leading neurodegeneration research program advancing our understanding of Parkinson’s disease and related disorders through cutting-edge translational neuroscience.

• Salary Package: $123,435 per annum (Level B.1), plus 17% superannuation & annual leave loading.
• 2x full-time (35 hours per week), fixed-term opportunities until May 31, 2029
• Location: Macquarie University Wallumattagal Campus, North Ryde, New South Wales.

About the Role

Join a world-leading translational neuroscience research program at Macquarie University and contribute to internationally collaborative projects investigating the mechanisms underlying Parkinson’s disease and related neurodegenerative disorders.

We are seeking to appoint up to two Postdoctoral Research Fellows to work within a highly collaborative neurodegeneration research environment focused on understanding neuronal vulnerability, disease progression, sleep and cognitive dysfunction, and biological heterogeneity in Parkinson’s disease and related proteinopathies.

These complementary projects integrate human postmortem brain tissue analysis, advanced histopathology, molecular neuroscience, imaging, transcriptomics, and disease modelling approaches to investigate the cellular and molecular drivers of neurodegeneration.

Depending on project alignment and expertise, the successful candidate(s) may contribute to research involving:

• Multiplex immunolabelling, fluorescence imaging, and digital pathology workflows for alpha-synuclein and tau-related disease mechanisms
• Followed by quantitative image analysis and interpretation of complex experimental datasets
• Molecular pathology techniques including proximity ligation assays and related approaches
• These approaches will be used in mouse and human postmortem brain tissues to assess sleep and cognitive dysfunction in Parkinson’s disease
• These approaches will be used in human postmortem brain tissue to assess RNA biological changes with neuronal degeneration and resilience in Parkinson’s disease

The successful candidate(s) will contribute to experimental design, laboratory-based investigations, data analysis, and dissemination of research findings through publications, presentations, and collaborative discussions with internal and international research partners.

This is an exciting opportunity to work at the forefront of neurodegeneration research within a globally recognised neuroscience research environment leveraging state-of-the-art laboratory and analytical approaches.