"Postdoctoral Research Fellow - Reinherz Lab"

The Reinherz lab at Dana-Farber Cancer Institute and Harvard Medical School is recruiting a postdoctoral fellow to study HIV-1 vaccine immunology.

We use an interdisciplinary approach combining structural biology, molecular biology, biochemistry, and immunology to generate insights that can be translated into HIV-1 vaccine design. Specific research areas of interest include molecular and cellular mechanisms underlying B cell immunodominance and strategies to modulate B cell affinity maturation during vaccination to induce protective immunity while preventing induction of autoimmunity.

The laboratory provides a rich training environment and access to cutting-edge techniques.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities:

• The postdoctoral fellow will work on HIV-1 env vaccine development and modulation of B cell affinity maturation.
• He or she will investigate structure-guided immunogen design and innovative vaccine strategies aimed at enhancing subdominant antibody responses.
• Mouse model immunization studies, immune sera analyses, FACS for immune cells analyses, B cell repertoire analysis and immunohistology are key tasks along with cloning, expression and purification of proteins, cell culture, etc.

Qualifications:

• Highly-motivated candidates with a recent PhD or MD/PhD in biomedical sciences
• Significant experience in immunology, molecular biology, and biochemistry are encouraged to apply.
• Technical experience in immunology and methods to examine immune responses (measurement of antibodies, B and T cell responses and B cell repertoire analyses and mouse modeling/handling etc.) are essential.

Knowledge, Skills, and Abilities:

• Skills in molecular cloning, biochemistry and cell culturing techniques/protein expression are highly desirable.
• Candidates should have a publication record in peer-reviewed journals.
• We are seeking a candidate with excellent writing and communication skills, able to work independently but also effectively with other lab members.

Please include the following information with your Resume/CV:

• Cover letter briefly summarizing your research interests and career goals
• Contact information for three references