"Postdoctoral Researcher"

About Us

Are you a highly motivated postdoctoral researcher with a strong background in human immunology? We're seeking a skilled scientist to join the Autoimmunity and Immune Regulation Team, led by Professor Tim Tree, at King's College London.

Our team focuses on understanding the immune system's role in autoimmune and inflammatory diseases and exploring immunotherapy to treat them. This exciting project involves characterising samples from a recently completed Phase II clinical trial for amyotrophic lateral sclerosis (ALS).

About the role

The project's primary goal is to investigate how low-dose IL-2 affects the neuro-inflammatory process. You'll use advanced cellular immunology techniques to conduct deep phenotypic and functional characterisation of regulatory T cells (Tregs), establishing their relationship with treatment responses and disease activity.

This is an excellent opportunity to contribute to a collaborative research program dedicated to improving our understanding of ALS and informing future clinical trials. You'll also benefit from being part of a larger team investigating Treg biology and Treg-focused immunotherapies in other diseases.

The ideal candidate will have a strong background in cellular immunology and be proficient in analysing complex single-cell data. We utilise cutting-edge techniques, including high-dimensional flow cytometry (using CyTek Aurora) and single-cell transcriptional profiling (using 10x Genomics).

Excellent communication skills and a passion for learning new assays and analysis techniques are essential.

The position is based at Guy's Hospital, giving you access to state-of-the-art core facilities for flow cytometry, genomics, and bioinformatics. This role provides a unique opportunity for an ambitious scientist to advance their career in translational immunology.

This is a full time post (35 hours per week), and you will be offered a fixed term contract for 18 months.

Research staff at King’s are entitled to at least 10 days per year (pro-rata) for professional development. This entitlement, from the Concordat to Support the Career Development of Researchers, applies to Postdocs, Research Assistants, Research and Teaching Technicians, Teaching Fellows and AEP equivalent up to and including grade 7. Visit the Centre for Research Staff Development for more information.

About You

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. PhD qualified in relevant subject area *
2. An excellent theoretical and practical knowledge of the human immune system
3. Extensive experience of immunology-focused laboratory assays
4. Extensive experience of flow cytometry

* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Desirable criteria

1. Experience of working with clinical trial samples under GCLP guidelines
2. Experience of analysing complex single-cell data sets

Further Information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.

As part of this commitment to equality, diversity and inclusion and through this appointment process, it is our aim to develop candidate pools that include applicants from all backgrounds and communities.

We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages.

This post is subject to Occupational Health clearance.

Grade and Salary: £45,031 per annum, including London Weighting Allowance

Job ID: 123345

Close Date: 07-Sep-2025

Contact Person: Professor Timothy Tree

Contact Details: Timothy.tree@kcl.ac.uk