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Postdoctoral Researcher in Human Disease Modelling

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University of Oxford

Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford

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Postdoctoral Researcher in Human Disease Modelling

Postdoctoral

1 May 2026 (noon)

Location

John Radcliffe Hospital, Headington, Oxford

University of Oxford

Type

Full-time, fixed-term until 31 March 2028

Required Qualifications

PhD/DPhil in life sciences
Post-doctoral research experience
Primary patient cell culture
Omics assays
Cytotoxicity assays
Molecular biology techniques
Supervisory experience
Strong publication record

Research Areas

Human organoid models
Blood and immune cell production
Multiple myeloma therapies
3D cell culture systems
Drug combination efficacy
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Postdoctoral Researcher in Human Disease Modelling

We are seeking a Postdoctoral Researcher to join the newly established research group led by Dr Abdullah Khan, under the joint supervision multiple myeloma clinician scientist Dr Sarah Gooding. Dr Khan’s research develops and applies human organoid models to investigate the basic processes of blood and immune cell production, and how these mechanisms are disrupted in ageing and disease.

This research is an industrial collaboration investigating synergistic mechanisms of drug action in the context of myeloma. The project will involve assessing the efficacy of different combinations of myeloma therapies on cell lines and primary patient cells grown in 3D model systems.

You will hold a PhD/DPhil in the life sciences and have completed a period of post-doctoral research. You will have experience of culturing primary patient material, and using said samples for a number of different downstream assays. Experience of omics and cytotoxicity assays are required. A broad background in molecular biology techniques is essential, with an ability to manage your own research including experience in supervising others. Excellent communication skills and a strong publication record are required. Experience in flow cytometry and 3D cell culture with an interest in translational research is desirable.

The post is available on a full-time basis and is fixed-term until 31 March 2028, funded by GlaxoSmithKline.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is noon on Friday 1 May 2026.

Location: Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford

H826012 Job Description Selection Criteria Post Doc Final.pdf (586.2 KB)

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Frequently Asked Questions

🎓What qualifications are required for this Postdoctoral Researcher in Human Disease Modelling role?

You must hold a PhD/DPhil in life sciences and have completed postdoctoral research. Essential experience includes culturing primary patient material, omics assays, cytotoxicity assays, and molecular biology techniques. A strong publication record and supervisory skills are required. Desirable: flow cytometry and 3D cell culture. Learn more about thriving in postdoctoral roles.

🔬What is the research focus of this multiple myeloma organoid modelling position?

The project develops human organoid models to study blood/immune cell production disruptions in ageing and multiple myeloma. It assesses drug combination efficacy using cell lines and primary patient cells in 3D model systems, in collaboration with GlaxoSmithKline. Explore related postdoc opportunities in research.

📝How do I apply for this Postdoc Human Disease Modelling job at Oxford?

Applications are online only: upload a CV and supporting statement. Closing date is noon on 1 May 2026. Review the full job description PDF linked in the post. Tips for postdoc applications available.

💰What is the duration, employment type, and funding for this position?

Full-time, fixed-term until 31 March 2028, funded by GlaxoSmithKline as an industrial collaboration. No salary details provided; check similar research jobs for benchmarks.

📍Who supervises this Postdoctoral Researcher role and where is it located?

Led by Dr Abdullah Khan, joint supervision with Dr Sarah Gooding. Located at Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford. View Oxford postdoc positions.

What skills are desirable for success in this organoid modelling research?

Desirable: experience in flow cytometry and 3D cell culture, plus interest in translational research. Excellent communication and ability to manage independent research required. Build your profile with advice on research assistant excellence.
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