12 Aug 2026
Job Information
Organisation/Company: INSERM
Department: UMR 1087 / CNRS UMR 6291
Research Field: Physics » Computational physics; Computer science » Programming
Researcher Profile: Recognised Researcher (R2)
Positions: Postdoc Positions
Application Deadline: 11 Sep 2026 - 23:59 (Europe/Paris)
Country: France
Type of Contract: Temporary
Job Status: Full-time
Offer Starting Date: 1 Nov 2026
Is the job funded through the EU Research Framework Programme?: Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?: Yes
Offer Description
The CElNext project (A Next-generation Mathematical Model of Cardiac Electrophysiology) aims to develop a spatially resolved, multiscale computational framework linking subcellular ion-channel organization to cellular and tissue-level cardiac electrical behaviour, with applications to arrhythmogenic mechanisms including Brugada syndrome. The postdoctoral researcher will focus on the numerical development and implementation of ultrastructure-resolved cardiomyocyte models and will work at the interface of applied mathematics, scientific computing, computational biophysics and cardiac electrophysiology.
Main Activities
- Develop and validate a high-resolution TT-JSR dyadic microdomain model.
- Implement stochastic calcium-release-unit (CRU) dynamics and localized electrodiffusion formulations.
- Integrate dyadic modules into a geometrically resolved whole-cell EMI cardiomyocyte model.
- Implement and run large-scale numerical simulations, parameter sweeps and sensitivity analyses.
- Contribute to simulation campaigns for extraction of scale-preserving electrophysiological descriptors.
Associated Activities
- Collaborate with electrophysiology and ion-channel experts at l'Institut du thorax.
- Document code and contribute to open-source software and reproducible workflows.
- Analyse results, prepare manuscripts and present work at scientific meetings/conferences.
- Contribute to supervision and scientific exchanges within the CElNext team.
Where to apply
E-mail: rupamanjari.majumder@inserm.fr
Requirements
Research Field: Physics » Computational physics
Education Level: PhD or equivalent
Research Field: Computer science » Programming
Education Level: PhD or equivalent
Research Field: Mathematics » Computational mathematics
Education Level: PhD or equivalent
Skills/Qualifications
- PhD in applied mathematics, computational science, scientific computing, physics, computational biophysics, biomedical engineering, or a closely related field.
- Strong background in numerical methods for differential equations and scientific computing.
- Proficiency in C++, Python, or comparable scientific-programming languages.
- Experience with PDE-based modelling, stochastic processes and/or biophysical simulation is highly desirable.
- Ability to work independently and collaboratively in an interdisciplinary environment;
- Good scientific communication skills.
Specific Requirements
- Strong computational component; regular use of Linux/HPC environments and large numerical simulations.
- Occasional scientific travel/collaboration visits may be required.
Languages: ENGLISH
Level: Excellent
Research Field: Physics » Computational physics
Years of Research Experience: 1 - 4
Research Field: Physics » Biophysics
Years of Research Experience: 1 - 4
Additional Information
Additional comments
Type of offer: Fixed-term postdoctoral researcher contract (CDD chercheur)
Duration: 12 months renewable once, full time
Salary: Between 2 939 € et 3 336 € gross salary based on professional experience
Work Location(s)
Number of offers available: 1
Company/Institute: l'institut du thorax
Country: France
Contact
City: Nantes
Website: https://www.inserm.fr/
Street: 8 quai Moncousu
Postal Code: 44007
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