1. Protein quality control, aging, and neurodegenerative diseases
Our laboratory has discovered two previously unrecognized protein quality control (PQC) systems involving tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins. These pathways function independently of ATP and exhibit distinct evolutionary conservation-TRIM in animals and polyD/E across eukaryotes-setting them apart from established PQC mechanisms. Ongoing work aims to define their molecular mechanisms, elucidate their contributions to aging and neurodegenerative diseases (Alzheimer's, Parkinson's, ALS), and explore their potential for therapeutic intervention.
2. Tumor suppression, metabolism, and autophagy
We examine the regulatory mechanisms and functional roles of the tumor suppressor p53, with emphasis on its control of metabolic pathways essential for biosynthesis and redox balance. Our studies explore how p53 integrates metabolic cues by acting as both a sensor and regulator of cellular metabolism. In parallel, we are identifying metabolic changes that promote tumor initiation and progression. This work has recently expanded to include investigations into how metabolism and autophagy influence the biology of embryonic and cancer stem cells.
Qualifications
Applicants should hold, or be nearing completion of, a PhD or MD degree and demonstrate a strong publication record, rigorous experimental skills, and relevant experience in areas such as biochemistry, cell biology, molecular biology, metabolism, stem cell biology, neuroscience, cancer research, or animal models.
Application Instructions
Review of applications will begin immediately and will continue until the position is filled.
