"Postdoctoral Scientist - Neurobiology - Dr Anne Bertolotti - LMB 2701"

The position is for a Postdoctoral Scientist with expertise on cryoEM and/or protein biochemistry. You will be responsible for expressing, purifying phosphatases and kinases and solving their structures using a combination of approaches primarily cryoEM and or and/or crystallography (with the support of LMB facilities). You may also develop new inhibitors and conduct functional studies.

Dr Anne Bertolotti’s pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al,. Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024). The small molecules discovered by the lab are currently tested in clinical trials for neurodegenerative diseases. You will provide fundamental structural and mechanistic insights on these important enzymes and expand on the next generation of inhibitors.

You will join a strong inter-disciplinary team at the LMB, which has broad expertise extending from biochemistry, structural, chemical, molecular and cell biology through to transgenic animal models of degenerative diseases. The team also has an excellent record of innovative basic research leading to applications in medicine.

Further information about the position may be obtained from Dr Anne Bertolotti via email: aberto@mrc-lmb.cam.ac.uk.

You will be ambitious, creative and fearless, able to invent new approaches to explore the unknown. You will have a PhD in biochemistry or structural biology or due to complete doctoral studies within 6 months of applying. Relevant experience is required, and this must be best attested by at least one impactful and original publication. Interests in signaling enzymes is desirable.

This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).

If you are unable to apply online please contact us at recruit@mrc-lmb.cam.ac.uk.

Closing date: 21/09/2025

Final appointments will be subject to a pre-employment screening.

We actively support equality, diversity and inclusion in all our activities, processes and culture.

We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; recruit@mrc-lmb.cam.ac.uk.