Postdoctoral Scientist - Neurobiology – Dr Anne Bertolotti - LMB 2792

MRC Laboratory of Molecular Biology

Dr Anne Bertolotti’s pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al,. Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024; Miguel, C. D. et al. Science eadw5137 (2025)).

The position is for a Postdoctoral Scientist with expertise on cryoEM and/or protein biochemistry. You will be responsible for expressing, purifying phosphatases and kinases and solving their structures using a combination of approaches, primarily cryoEM and or and/or crystallography, with the support of LMB facilities. You will have a PhD in biochemistry or structural biology or due to complete doctoral studies within 6 months of applying. Relevant experience is required, and this must be best attested by at least one impactful and original publication.

This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.

The LMB has a collaborative working culture and state-of-the-art building on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. We have a staff restaurant with roof terrace and access to a Campus nursery and sports and social facilities. You will be eligible to join our defined benefit pension scheme, a holiday entitlement of 40.5 days per annum (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications. Further information about the benefits available can be found at http://www.discover.ukri.org/benefits-of-working-at-ukri.

The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.

To apply and access full details of the vacancy please visit our job board via the 'Apply' button above.

If you are unable to apply online please contact us at recruit@mrc-lmb.cam.ac.uk.

Final appointments will be subject to a pre-employment screening.

We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; recruit@mrc-lmb.cam.ac.uk.