Research Assistant in Genome Editing

University of Oxford - Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital

Location: Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS

We are seeking a highly motivated Research Assistant to join, the new MRC Centre of Research Excellence in Therapeutic Genomics programme. The postholder will join Professors James Davies and Ronjon Chakraverty in researching genome editing methods for treating patients with primary immune deficiencies. The research project combines advanced genome editing and genomics approaches.

You will work to develop novel gene editing strategies that can eventually be used in clinical trials, managing your own research including laboratory experiments and analysis, with guidance provided by senior colleagues. Responsibilities include writing Standard Operating Procedures for use of reagents and equipment, quality assurance and quality control, ensuring standardisation and reproducibility of biological assays, nucleic acid sequencing and analysis.

You will hold an undergraduate degree in biomedical sciences with a working knowledge of data analysis including statistical analysis of data. Experience of molecular biology techniques, cell culture with an understanding of methods of purifying cell populations is essential. Specialist knowledge and direct, practical experience in CRISPR-based genome editing is essential. Knowledge of genomics techniques including ChIP-seq, ATAC-seq, RNA-seq and chromosome conformation capture techniques are desirable.

The post is fixed-term for 3 years, funded by the Medical Research Council.

Applications are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12 noon on Tuesday 24 March 2026. Interviews will be held Tuesday 7 April 2026.