Principal Laboratory Cellular Profiling Research Scientist

Employer: Chemical Insights

Location: RTP, NC

Salary: Salary is commensurate with experience

Closing date: Jan 15, 2026

Discipline: Health Sciences, Public Health, Toxicology, Translational Research

Position Type: Full Time

Job Type: Senior Scientist

Organization Type: Non-Profit

Job Description

The Principal Laboratory Cellular Profiling Research Scientist will serve as a senior technical expert contributing to the design, execution, and communication of advanced high-throughput in vitro toxicology screening research efforts. This role leads high-impact projects in support of strategic initiatives that advance public health by assessing and mitigating human exposure to harmful chemicals and pollutants. The ideal candidate brings laboratory expertise in high-throughput applications for cell-based screening, e.g. high-throughput transcriptomics and/or high content imaging assays using semi-automated or automated liquid handling to enable accurate screening of 10s to 1000s of chemicals. This individual applies deep technical expertise in cellular and molecular toxicology, high-throughput in vitro screening, and environmental health to deliver actionable data, tools, and innovations that inform chemical safety, risk assessment, regulatory policy, and public awareness.

As the Principal Laboratory Cellular Profiling Research Scientist, you will play a key role as you:

• Lead the design, execution, and dissemination of complex high-throughput in vitro toxicology screening studies aligned with our mission.
• Optimize and apply cell-based, high-throughput in vitro assays that are designed to broadly profile biological processes and endpoints using high-throughput transcriptomics (i.e., next-generation sequencing technology) and high content imaging assays (e.g., cell painting) in a variety of cell models.
• Screen chemicals in these broad profiling, high-throughput in vitro assays to identify concentrations at which chemicals may disrupt important biological processes and endpoints.
• Collaborate with data scientists to analyze high-dimensional datasets, integrate transcriptomic and cellular feature read-outs, and make them publicly available.
• Characterize the performance of the in vitro assays and ensure high-throughput screening results meet applicable quality standards.
• Collaborate with internal and external stakeholders, including scientists, health professionals, regulatory agencies, and academic institutions.
• Translate complex technical findings into clear, actionable insights for diverse audiences, including the development of educational and risk communication materials.
• Serve as a principal investigator or lead author on high-visibility projects, technical reports, and peer-reviewed publications.
• Lead and participate in writing research proposals and securing funding from internal and external sources.
• Mentor and guide junior researchers, post-docs, and interns in laboratory methods, study design, and analysis.
• Represent our organization at national and international scientific conferences, workshops, and technical forums.
• Continuously monitor emerging scientific research, technologies, and regulatory trends to inform strategy and maintain technical leadership in toxicology and in vitro toxicity screening.
• Perform other duties as directed.